@article {1503146,
	title = {The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8~T Cell Function and Identifies Patients with SLE Prone to Infections},
	journal = {Cell Rep},
	volume = {30},
	number = {1},
	year = {2020},
	month = {2020 Jan 07},
	pages = {112-123.e4},
	abstract = {Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T~cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38 T~cell subset in a subgroup of patients with increased rates of infections. CD8CD38 T~cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38 T~cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T~cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T~cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically.},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2019.12.014},
	author = {Katsuyama, Eri and Suarez-Fueyo, Abel and Bradley, Sean J and Mizui, Masayuki and Marin, Ana V and Mulki, Lama and Krishfield, Suzanne and Malavasi, Fabio and Yoon, Joon and Sui, Shannan J Ho and Kyttaris, Vasileios C and Tsokos, George C}
}
