@article {1503186,
	title = {The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming},
	journal = {Cell Metab},
	volume = {27},
	number = {5},
	year = {2018},
	month = {2018 May 01},
	pages = {1040-1054.e8},
	abstract = {Nutrient deprivation induces autophagy through inhibiting TORC1 activity. We describe a novel mechanism in Drosophila by which TORC1 regulates RNA processing of Atg transcripts and alters ATG protein levels and activities via the cleavage and polyadenylation (CPA) complex. We show that TORC1 signaling inhibits CDK8 and DOA kinases, which directly phosphorylate CPSF6, a component of the CPA complex. These phosphorylation events regulate CPSF6 localization, RNA binding, and starvation-induced alternative RNA processing of transcripts involved in autophagy, nutrient, and energy metabolism, thereby controlling autophagosome formation and metabolism. Similarly, we find that mammalian CDK8 and CLK2, a DOA ortholog, phosphorylate CPSF6 to regulate autophagy and metabolic changes upon starvation, revealing an evolutionarily conserved mechanism linking TORC1 signaling with RNA processing, autophagy, and metabolism.},
	keywords = {Animals, Autophagy, Autophagy-Related Protein 8 Family, Autophagy-Related Protein-1 Homolog, Cyclin-Dependent Kinase 8, Drosophila melanogaster, Drosophila Proteins, Energy Metabolism, Gene Expression Regulation, HEK293 Cells, Humans, MCF-7 Cells, mRNA Cleavage and Polyadenylation Factors, Phosphorylation, Protein-Serine-Threonine Kinases, Protein-Tyrosine Kinases, RNA, RNA-Binding Proteins, Signal Transduction, Transcription Factors, Transcription, Genetic},
	issn = {1932-7420},
	doi = {10.1016/j.cmet.2018.02.023},
	author = {Tang, Hong-Wen and Hu, Yanhui and Chen, Chiao-Lin and Xia, Baolong and Zirin, Jonathan and Yuan, Min and Asara, John M and Rabinow, Leonard and Perrimon, Norbert}
}
