@article {1615971,
	title = {CXCR6 positions cytotoxic T~cells to receive critical survival signals in the tumor microenvironment},
	journal = {Cell},
	volume = {184},
	number = {17},
	year = {2021},
	month = {2021 Aug 19},
	pages = {4512-4530.e22},
	abstract = {Cytotoxic T lymphocyte (CTL) responses against tumors are maintained by stem-like memory cells that self-renew but also give rise to effector-like cells. The latter gradually lose their anti-tumor activity and acquire an epigenetically fixed, hypofunctional state, leading to tumor tolerance. Here, we show that the conversion of stem-like into effector-like CTLs involves a major chemotactic reprogramming that includes the upregulation of chemokine receptor CXCR6. This receptor positions effector-like CTLs in a discrete perivascular niche of the tumor stroma that is densely occupied by CCR7+ dendritic cells (DCs) expressing the CXCR6 ligand CXCL16. CCR7+ DCs also express and trans-present the survival cytokine interleukin-15 (IL-15). CXCR6 expression and IL-15 trans-presentation are critical for the survival and local expansion of effector-like CTLs in the tumor microenvironment to maximize their anti-tumor activity before progressing to irreversible dysfunction. These observations reveal a cellular and molecular checkpoint that determines the magnitude and outcome of anti-tumor immune responses.},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2021.07.015},
	author = {Di Pilato, Mauro and Kfuri-Rubens, Raphael and Pruessmann, Jasper N and Ozga, Aleksandra J and Messemaker, Marius and Cadilha, Bruno L and Sivakumar, Ramya and Cianciaruso, Chiara and Warner, Ross D and Marangoni, Francesco and Carrizosa, Esteban and Lesch, Stefanie and Billingsley, James and Perez-Ramos, Daniel and Zavala, Fidel and Rheinbay, Esther and Luster, Andrew D and Gerner, Michael Y and Kobold, Sebastian and Pittet, Mikael J and Mempel, Thorsten R}
}
